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Updated: Jan 4, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins
1Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Abstract:
Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid-liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.
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