Related Experiment Video

Updated: Jan 4, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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TYK2: An Upstream Kinase of STATs in Cancer

Katharina Wöss1, Natalija Simonović1, Birgit Strobl1

  • 1Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.

Cancers
|November 8, 2019
PubMed

Insights

Protein tyrosine kinase 2 (TYK2) has oncogenic potential, driving cancer through STAT3/5 activation. Dysregulated TYK2, including mutations, is implicated in various cancers, with potential therapeutic interventions discussed.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Protein tyrosine kinase 2 (TYK2) plays a critical role in cytokine signaling and immune responses.
  • Its involvement in carcinogenesis is increasingly recognized, particularly through the activation of STAT3 and STAT5 pathways.

Purpose of the Study:

  • To review recent findings on the oncogenic potential of TYK2.
  • To elucidate the role of TYK2 in cytokine responses, carcinogenesis, and immunological functions.

Main Methods:

  • Review of recent literature focusing on TYK2.
  • Analysis of data from loss-of-function studies in gene-modified mice and human patients with TYK2 mutations.
  • Reference to existing reviews for detailed structure/function and pathobiology.

Main Results:

  • Dysregulated TYK2 activation, elevated protein levels, and gain-of-function mutations are observed in various cancers.
  • TYK2 is central to immunological and inflammatory responses, as evidenced by genetic studies.
  • Aberrant TYK2 signaling contributes to cancer development and progression.

Conclusions:

  • TYK2 is a significant factor in cancer development and progression.
  • Understanding TYK2's role in cytokine signaling and immune evasion is crucial for cancer therapy.
  • Targeting TYK2 activity presents a potential therapeutic strategy for various cancers.
Keywords:
JAK family of protein tyrosine kinasescytokine receptor signalinggain-of-function mutationsignal transducer and activator of transcriptiontumorigenesistyrosine kinase 2

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