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Updated: Jan 4, 2026

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
Published on: June 7, 2024
Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health
I V Chicherin1,2, M V Baleva3, S A Levitskii3
1Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234, Russia. i.v.chicherin@gmail.com.
Abstract:
Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including translation initiation machinery. This review is dedicated to the mitochondrial translation initiation factor 3 (IF3mt), which plays a key role in the protein synthesis in mitochondria. Involvement of IF3mt in human health and disease is discussed.
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