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Subcutaneous teicoplanin in staphylococcal bone and joint infections
A L Destrem1, F Valour2, C Ronde-Ousteau3
1Service de maladies infectieuses, centre hospitalier Métropole Savoie, rue Lucien Biset, 73000 Chambéry, France.
Objective:
We aimed to describe the use of subcutaneous teicoplanin as an alternative for the treatment of staphylococcal bone and joint infections.
Methods:
A retrospective multicentric cohort (2002-2015) was conducted with patients receiving subcutaneous teicoplanin for a staphylococcal bone and joint infection.
Results:
Forty patients were assessed. A median loading dose of 9.4 mg/kg/12h (IQR, 6.1-13.1) was administered to 35 patients, subcutaneously for 18 of them. Thirteen of these patients received three injections per week. No excess risk of failure was identified. The trough level was not significantly different between the various routes (p=0.462), and was significantly higher if the loading dose was≥9 mg/kg/injection (p<10-3).
Conclusion:
The use of subcutaneous teicoplanin seems to be acceptable as an alternative to other routes of administration for antibiotics.
