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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

731
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
731

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Interleukin-6 elevation in healthy neonates.

Chinedu Ulrich Ebenebe1, Andrea Boiger2, Anna Perez2

  • 1Division of Neonatology and Pediatric Intensive Care, University Children's Hospital, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. c.ebenebe@uke.de.

Journal of Perinatology : Official Journal of the California Perinatal Association
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Summary
This summary is machine-generated.

Elevated Interleukin-6 (IL-6) in newborns without infection is linked to maternal fever, prolonged labor, vaginal birth, and higher neonatal neutrophils. Many infants tolerate high IL-6 levels without needing antibiotics.

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Area of Science:

  • Neonatal immunology
  • Perinatal medicine
  • Inflammatory markers

Background:

  • Interleukin-6 (IL-6) is a key inflammatory cytokine.
  • Elevated cord blood IL-6 in neonates can indicate intrauterine inflammation or stress.
  • Identifying factors associated with elevated IL-6 is crucial for appropriate neonatal care.

Purpose of the Study:

  • To identify peripartum and neonatal factors correlated with elevated Interleukin-6 (IL-6) levels in cord blood.
  • To assess the need for antibiotic treatment in neonates with elevated IL-6 but no clinical signs of infection.

Main Methods:

  • Prospective single-center study of healthy term and preterm neonates (March-November 2017).
  • Investigated correlations between 21 peripartum factors and neonatal IL-6 concentrations.
  • Included 471 infants with gestational ages ranging from 32.9 to 42.3 weeks.

Main Results:

  • Elevated neonatal IL-6 was associated with maternal temperature >37.5°C (OR 3.1, p=0.012).
  • Increased risk of elevated IL-6 linked to labor duration >12h (OR 4.5, p<0.001), vaginal delivery (p<0.001), and neonatal neutrophils >8×10⁹ cells/L (p<0.001).

Conclusions:

  • A significant number of neonates with elevated IL-6 can manage perinatal stress and intrauterine inflammation without antibiotics.
  • Elevated IL-6 alone does not necessitate postnatal antibiotic treatment in the absence of clinical infection signs.