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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Expression Of Cyclin D1 Protein Isoforms And Its Prognostic Significance In Cervical Cancer.

Jiahui Gu1, Xinyu Zhang2, Zhuo Yang1

  • 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110001, People's Republic of China.

Cancer Management and Research
|November 8, 2019
PubMed
Summary

Cyclin D1a and D1b expression in cervical cancer tissues was assessed. Neither cyclin D1a nor D1b expression correlated with cervical cancer prognosis, though lymph node metastasis is a factor in recurrence.

Keywords:
cervical cancercyclin D1 protein isoformsexpressionprognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gynecologic Pathology

Background:

  • Cyclin D1 is implicated in various cervical cancer stages.
  • Limited research exists on cyclin D1's prognostic value in cervical cancer.

Purpose of the Study:

  • To evaluate cyclin D1a and D1b expression in normal, precancerous (cervical intraepithelial neoplasia), and cancerous cervical tissues.
  • To determine the association between cyclin D1a and D1b expression and cervical cancer prognosis.

Main Methods:

  • Immunohistochemical staining was used to detect cyclin D1a and D1b expression.
  • The study included 78 primary cervical cancer cases, 40 cervical intraepithelial neoplasia cases, and 40 normal cervical tissue samples.

Main Results:

  • Cyclin D1a expression was higher in cervical cancer than in cervical intraepithelial neoplasia but not significantly different from normal tissue.
  • Cyclin D1b expression was higher in normal tissue compared to cervical cancer.
  • Lymph node metastasis was identified as a potential independent factor for postoperative recurrence (HR=0.240, P=0.034).

Conclusions:

  • Cyclin D1a expression correlated with tumor size and differentiation; cyclin D1b expression correlated with lymph node metastasis.
  • Cyclin D1a and D1b expression showed significant correlation within cervical cancer tissues.
  • Cyclin D1a and D1b expression levels were not found to be associated with cervical cancer patient prognosis.