Lanthony desaturated panel D15 test in sickle cell patients

Area of Science:

• Ophthalmology
• Hematology
• Medical Diagnostics

Background:

• Sickle cell retinopathy is a complication of sickle cell disease (SCD).
• Color vision impairment can occur in individuals with SCD.
• Early detection of visual complications is crucial for managing SCD.

Purpose of the Study:

• To compare color vision between sickle cell retinopathy patients and healthy controls using the Lanthony D15 desaturated test.
• To evaluate the effectiveness of the Lanthony D15 test in identifying color vision defects in SCD.
• To assess the correlation between the Lanthony D15 and Farnsworth Munsell 100 Hue tests.

Main Methods:

• The Lanthony D15 desaturated test was administered to sickle cell patients with retinopathy and 20/20 visual acuity, alongside normal controls.
• Error scores and types of color vision defects were recorded.
• Correlation analysis was performed between Lanthony D15 and Farnsworth Munsell 100 Hue test scores for patients with sickle cell anemia (SS).

Main Results:

• Sickle cell patients demonstrated significantly higher Lanthony error scores compared to controls.
• Blue-yellow and mixed color vision defects were more prevalent in sickle cell patients.
• A significant correlation was found between Lanthony D15 and Farnsworth Munsell 100 Hue test scores in SS patients.

Conclusions:

• The Lanthony D15 desaturated test is a valuable tool for detecting blue-yellow color vision defects in sickle cell retinopathy.
• The test's simplicity and brevity make it suitable for clinical use in SCD management.
• Findings support the utility of the Lanthony D15 test in identifying color vision abnormalities associated with SCD.