Related Experiment Video
Updated: Jan 4, 2026
13:47
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
26.1K
DNA methylation and inflammatory skin diseases
Joshua S Mervis1, Jean S McGee2
1Department of Dermatology, Boston University School of Medicine, 609 Albany Street, J-505, Boston, MA, 02118, USA.
Archives of Dermatological Research
|November 8, 2019
Summary
Epigenetics, changes in gene expression without altering DNA, is key in skin diseases. This review focuses on DNA methylation
Area of Science:
- Dermatology and Epigenetics: Exploring the molecular mechanisms behind skin conditions.
Background:
- Epigenetics involves heritable gene expression changes without DNA sequence alteration, including DNA methylation and histone modification.
- Epigenetic dysregulation is linked to various diseases, notably cutaneous T-cell lymphoma (CTCL), leading to targeted therapies.
- The role of epigenetics in inflammatory skin diseases like psoriasis and atopic dermatitis is increasingly recognized.
Purpose of the Study:
- To provide an overview of DNA methylation's role in inflammatory skin diseases.
- To emphasize the investigation of DNA methylation in psoriasis and atopic dermatitis.
Main Methods:
- This is a review article, synthesizing existing research on epigenetics in dermatology.
- Focuses on studies investigating DNA methylation patterns in specific inflammatory skin conditions.
Main Results:
- Epigenetic modifications, particularly DNA methylation, are implicated in the pathogenesis of inflammatory skin diseases.
- Research highlights significant epigenetic changes in psoriasis and atopic dermatitis.
Conclusions:
- DNA methylation is a critical epigenetic mechanism in inflammatory skin diseases.
- Further research into DNA methylation in psoriasis and atopic dermatitis is warranted for potential therapeutic strategies.
Related Concept Videos
01:23Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
432
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
432
01:37Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
01:46Epigenetic Regulation
33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
416
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
416
01:30Inflammatory Bowel Disease II: Crohn's Disease
890
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
890