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Novel Targets for the Treatment of Melanoma

Lara Ambrosi1, Shaheer Khan2, Richard D Carvajal3

  • 1Stony Brook SOM, 101 Nicholls Rd, Stony Brook, NY, 11794, USA.

Current Oncology Reports
|November 8, 2019
PubMed
Abstract

Insights

This review covers current and novel treatments for metastatic melanoma, highlighting advances in immunotherapy and targeted therapy. Further research is crucial to overcome treatment resistance and improve patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Metastatic melanoma treatment has advanced significantly with immunotherapy and targeted therapy.
  • Despite progress, many patients eventually experience disease progression on current treatments.
  • Durable responses are achieved in a subset of patients, but resistance remains a challenge.

Purpose of the Study:

  • To review the current treatment landscape for metastatic melanoma.
  • To provide a comprehensive update on emerging novel treatment strategies for advanced melanoma.

Main Methods:

  • Literature review of current and emerging treatment strategies for metastatic melanoma.
  • Analysis of recent clinical trial data and research findings.

Main Results:

  • Immunotherapy and targeted therapy have improved outcomes but do not benefit all patients.
  • Ongoing trials explore novel combinatorial strategies, checkpoint inhibitors, immune agonists, and T cell-based therapies.
  • Intratumoral agents and other innovative approaches are under investigation.

Conclusions:

  • Significant progress has been made in treating advanced melanoma.
  • Further research is necessary to identify new targets and overcome treatment resistance.
  • Achieving better clinical outcomes requires continued investigation into alternative immune and molecular targets.
Keywords:
BRAF inhibitorCTLA-4Checkpoint inhibitorsImmunotherapyMEK inhibitorMelanomaOncolytic therapyPD-1PD-L1Targeted therapy

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