Ortho/Ipso Alkylborylation of Aryl Iodides
Xianwei Sui1, Thiago A Grigolo1, Colin J O'Connor1
1Department of Chemistry and Biochemistry , Florida State University , 95 Chieftan Way , Tallahassee , Florida 32306 , United States.
Abstract:
This work describes a method for the difunctionalization of aryl iodides to generate polysubstituted arenes via Pd catalysis. The reaction hinges on the unique interplay between norbornene and the metal catalyst to impart a guided ortho C-H alkylation event followed by a programmatic ipso borylation to provide a diverse array of substituted arene products. The utility of this transformation is demonstrated through the functionalization of the boronic ester to a variety of valuable functionalities.
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