Profile of renal diseases in North-East Indian children

Rimjhim Sonowal1

  • 1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Insights

Pediatric kidney diseases, including nephrotic syndrome and glomerulonephritis, are common in hospitalized children in Northeast India. Many of these renal diseases are preventable and treatable with timely medical intervention.

Area of Science:

  • Pediatric Nephrology
  • Internal Medicine
  • Public Health

Background:

  • Renal disease patterns vary globally due to genetic, socioeconomic, and infectious factors.
  • Limited data exists on the spectrum of pediatric renal diseases in India.
  • This study addresses the knowledge gap in Northeast India.

Purpose of the Study:

  • To investigate the profile and prevalence of renal diseases in hospitalized children in Northeast India.
  • To identify the most common pediatric renal diseases and their causes.
  • To highlight the burden and potential preventability of these conditions.

Main Methods:

  • A cross-sectional study was conducted in a tertiary care government medical college in Assam.
  • Hospitalized children over a one-year period were assessed for renal disease.
  • Diagnosis was based on medical history, clinical examination, and laboratory investigations.

Main Results:

  • 7.17% of admitted children had renal diseases.
  • Nephrotic syndrome was the most prevalent, followed by glomerulonephritis.
  • Acute post-infectious glomerulonephritis and septicemia (causing acute kidney injury) were common.

Conclusions:

  • Renal diseases represent a significant cause of pediatric morbidity in the region.
  • A majority of these kidney diseases are treatable.
  • Infective etiologies contribute substantially, indicating potential for prevention.

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
505
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
525
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
309
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
231
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.1K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
152