Related Experiment Video
Updated: Jan 4, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Type 1 diabetes and MIG
1Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Abstract:
In Type 1 Diabetes (T1D), the monokine induced by interferon (IFN)-γ (MIG)/(C-X-C motif) receptor (CXCR)3 axis has a crucial role in β-cell destruction and in the autoimmune process of the disease, like many papers have reported. In fact, in T1D subjects the serum levels of the Type helper 1 chemokine MIG is increased, suggesting that this chemokine could be a predictive marker of T1D. Moreover, the pathophysiology of the disease course could be assessed by measuring MIG serum levels. A potential approach for T1D therapy could be the block of MIG expression at the beginning of the disease. Anyway, the chemokines-cytokines interactions in the T1D pathogenesis need to be further investigated.
More Related Videos
10:03Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
11:31High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...