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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jan 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

SETD2 Mutation in an Aggressive Optic Nerve Glioma

Ashley A Campbell^1,2, Robyn D Gartrell-Corrado³, Mahesh Mansukhani⁴

¹Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

JAMA Ophthalmology

|November 8, 2019

Summary

No abstract available in PubMed .

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