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Updated: Jan 4, 2026

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A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage
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Evaluation of an automatic article selection method for timelier updates of the Comet Core Outcome Set database
Christopher R Norman1, Elizabeth Gargon2, Mariska M G Leeflang3
1LIMSI, CNRS, Université Paris-Saclay, Bât 507, rue du Belvédère, Campus Universitaire, F-91405 Orsay.
Database : the Journal of Biological Databases and Curation
|November 8, 2019
Summary
Machine learning significantly reduces workload for scientific literature screening. This approach can decrease screening efforts by 75% while missing only 2% of relevant references.
Area of Science:
- Bibliometrics
- Information Science
- Computational Biology
Background:
- Manually screening scientific literature for curated databases is labor-intensive.
- The Comet Core Outcome Set database relies on manual screening, leading to time-consuming updates.
- Efficient literature searching is crucial for researchers.
Purpose of the Study:
- To evaluate machine learning methods for reducing the workload of manual literature screening.
- To assess the effectiveness of a logistic regression model in automatically ranking candidate articles for the Comet database.
- To determine if machine learning can facilitate more timely updates of systematic review databases.
Main Methods:
- A machine learning approach using logistic regression was employed to rank candidate articles.
- Data from the original systematic review and four subsequent updates were used for model training and evaluation.
- Performance was assessed based on workload reduction and the rate of missed references.
Main Results:
- The study estimated a workload reduction of at least 75% using automated screening.
- The proposed machine learning method is expected to keep the number of missed references at approximately 2%.
- This trade-off was deemed acceptable for the systematic review process.
Conclusions:
- Machine learning offers a viable solution to reduce the manual workload in curating scientific literature databases.
- The evaluated logistic regression model provides an efficient method for prioritizing articles in systematic reviews.
- The successful application of this method is being implemented for future updates of the Comet database.
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