Related Experiment Video
Updated: Jan 4, 2026

Application of AlDeSense to Stratify Ovarian Cancer Cells Based on Aldehyde Dehydrogenase 1A1 Activity
Published on: March 31, 2023
Aldehyde dehydrogenase-2 as a therapeutic target
Mitsuru Kimura1, Akira Yokoyama1, Susumu Higuchi1
1National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Kanagawa, Japan.
Aldehyde dehydrogenase-2 (ALDH2) deficiency impacts disease risk and alcohol addiction. ALDH2 activators show promise in reducing cardiac damage and neurodegeneration, highlighting its therapeutic potential.
Area of Science:
- Biochemistry
- Pharmacology
- Genetics
Background:
- Aldehyde dehydrogenase-2 (ALDH2) is crucial for alcohol metabolism and detoxifying endogenous aldehydes.
- ALDH2 genetic variations can lead to flushing responses and affect alcohol consumption.
- ALDH2 also metabolizes neurotransmitter byproducts in the central nervous system.
Purpose of the Study:
- To review the role of ALDH2 polymorphism in disease, aging, and alcohol addiction.
- To discuss the potential of pharmacological targeting of ALDH2.
Main Methods:
- Literature search of PubMed and Cochrane Library up to August 2019.
- Analysis of case-control studies and animal models.
Main Results:
- ALDH2 deficiency is linked to increased risk of various diseases.
- ALDH2 activator Alda-1 demonstrated cardioprotective effects in animal models.
- Alda-1 also showed protective effects against neurodegenerative diseases.
Conclusions:
- ALDH2 is a significant therapeutic target for multiple diseases.
- Further research is needed to fully establish ALDH2's clinical potential.
More Related Videos
08:57Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
14:32Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
Related Concept Videos
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Alzheimer's Disease: Treatment
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Allosteric Regulation
Alcohols from Carbonyl Compounds: Reduction
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Dehydration of Aldols to Enals: Base-Catalyzed Aldol Condensation