An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy

Mollie R Freedman-Weiss1, Alexander S Chiu1, David Worhunsky1

  • 1Yale University School of Medicine, New Haven, CT.

Insights

Most young patients undergoing laparoscopic appendectomy do not need opioids post-discharge. Prescribing sparingly, no more than 25 morphine milligram equivalents (MME), is recommended to curb opioid overprescription.

Area of Science:

  • Pediatric Surgery
  • Pain Management
  • Public Health

Background:

  • Surgeon overprescription of opioids contributes to the ongoing opioid epidemic.
  • Lack of clear guidelines for pediatric and young adult post-surgical opioid prescribing exists.

Purpose of the Study:

  • To determine postoperative opioid requirements in pediatric and young adult patients after laparoscopic appendectomy.
  • To inform opioid prescribing guidelines for this demographic.

Main Methods:

  • A study included patients aged 5-20 years who underwent laparoscopic appendectomy.
  • Data collected via chart review and caregiver interviews on analgesic use and pain relief adequacy.
  • Opioid consumption quantified in morphine milligram equivalents (MME).

Main Results:

  • 83% of interviewed patients (49 total) did not use or desire opioids post-discharge and reported low pain levels (<4/10).
  • Five patients used an average of 23 MME (approx. 3 pills of 5mg oxycodone).
  • No patients who avoided opioids required unplanned follow-up for pain.

Conclusions:

  • The majority of pediatric and young adult patients achieve adequate pain relief after laparoscopic appendectomy without opioids.
  • Opioid prescriptions for this procedure should be limited, ideally not exceeding 25 MME.
Abstract

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
429
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
853
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
789
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
2.0K
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
181