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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Replacement for patellofemoral arthritis.
David Sands Johnson1, Philip Gartside Turner1
1Department of Trauma and Orthopaedics, Stockport NHS Foundation Trust, Aspen House, Stepping Hill Hospital, Poplar Grove, Stockport SK2 7JE, United Kingdom of Great Britain and Northern Ireland; School of Health and Society, Mary Seacole Building, University of Salford, Frederick Road Campus, Salford M6 6PU, United Kingdom of Great Britain and Northern Ireland.
Patellofemoral osteoarthritis (PFOA) affects many older adults. Both total knee replacement (TKR) and patellofemoral replacement (PFR) can treat end-stage PFOA, with shared decision-making crucial for patient outcomes.
Area of Science:
- Orthopedic surgery
- Rheumatology
- Biomedical engineering
Background:
- Patellofemoral osteoarthritis (PFOA) is prevalent in individuals over 55, with higher incidence in females.
- Conservative treatments are common, but arthroplasty is indicated for end-stage PFOA.
- A debate exists regarding the superiority of total knee replacement (TKR) versus patellofemoral replacement (PFR) for PFOA.
Purpose of the Study:
- To review current evidence comparing TKR and PFR for the surgical management of PFOA.
- To inform clinical decision-making for patients with end-stage patellofemoral osteoarthritis.
Main Methods:
- Systematic review of recent meta-analyses, systematic reviews, and cohort studies on PFOA surgical management.
- Inclusion of institutional patient data.
- Content based on a lecture presented at the British Association for Surgery of the Knee 2019.
Main Results:
- PFOA is distinct from tibiofemoral osteoarthritis (TFOA).
- Patellofemoral replacement (PFR) demonstrates a higher failure rate compared to total knee replacement (TKR).
- Evidence suggests potentially better outcomes and recovery in the PFR group, though patient subsets show variable results.
Conclusions:
- Both PFR and TKR are viable surgical options for PFOA.
- Preoperative counseling and shared decision-making are essential for patient selection between TKR and PFR.
- Further research is needed to elucidate outcome differences between procedures and within PFOA patient subsets.
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