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Relationship between left ventricular isovolumic relaxation flow patterns and mitral inflow patterns studied by using

Yu Han1, Liang Huang2, Zhiguo Li3

  • 1Graduate School of Dalian Medical University, Dalian, China.

Scientific Reports
|November 9, 2019
PubMed

Insights

Isovolumic relaxation flow (IRF) patterns in the left ventricle (LV) correlate with mitral inflow patterns. These IRF patterns show potential as a new index for assessing LV diastolic function.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Physiology

Background:

  • Left ventricular (LV) diastolic dysfunction is a significant clinical issue.
  • Assessing diastolic function typically relies on mitral inflow patterns.
  • Novel methods for evaluating diastolic function are needed.

Purpose of the Study:

  • To investigate the relationship between isovolumic relaxation flow (IRF) patterns in the LV and mitral inflow patterns.
  • To determine if IRF patterns can serve as an index for LV diastolic function.

Main Methods:

  • Vector flow mapping using Color Doppler was performed in the apical long-axis view.
  • IRF patterns were classified into three categories: A (apically directed flow), B (bidirectional flow with small vortices), and C (large vortex).
  • The study included patients with coronary artery disease, dilated cardiomyopathy, and healthy controls.

Main Results:

  • Normal LV filling and normal controls predominantly showed pattern A.
  • Impaired relaxation and pseudonormal filling showed a mix of patterns A, B, and C.
  • Restrictive filling was strongly associated with pattern C (78%) and pattern B (22%).
  • A significant association was found between IRF patterns and LV filling patterns (χ² = 52.026, p < 0.001).

Conclusions:

  • Isovolumic relaxation flow patterns are significantly related to LV filling patterns.
  • IRF patterns demonstrate potential as a novel index for evaluating LV diastolic function.

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