Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

7.7K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.2K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.2K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K
Membrane Fluidity01:26

Membrane Fluidity

14.3K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
14.3K
Cell Migration01:19

Cell Migration

6.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.3K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.7K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

easytrack: A napari plugin for automated parameter tuning in cell tracking.

microPublication biology·2026
Same author

Author Correction: A mechanical ratchet drives unilateral cytokinesis.

Nature·2026
Same author

3D epithelial cell topology tunes signaling range to promote precise patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Phyllotaxis in a Keller-Segel model.

Physical review. E·2026
Same author

Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.

Current biology : CB·2026
Same author

A mechanical ratchet drives unilateral cytokinesis.

Nature·2026
Same journal

Simple input-output dependencies explain neuronal activity.

Nature physics·2026
Same journal

Scaling and self-similarity in the formation of the embryonic epigenome.

Nature physics·2026
Same journal

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues.

Nature physics·2026
Same journal

The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport.

Nature physics·2026
Same journal

Squeezing, trisqueezing and quadsqueezing in a hybrid oscillator-spin system.

Nature physics·2026
Same journal

Noise-induced shallow circuits and the absence of barren plateaus.

Nature physics·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing
08:34

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing

Published on: January 2, 2018

9.9K

Tissue Fluidity Promotes Epithelial Wound Healing.

Robert J Tetley1,2, Michael F Staddon2,3, Davide Heller4,5

  • 1MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Nature Physics
|November 9, 2019
PubMed
Summary
This summary is machine-generated.

Altering epithelial cell junctional tension in Drosophila wing discs influences wound healing rates. Reducing tension increases cell intercalation and fluidizes tissue, accelerating healing.

More Related Videos

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.1K
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

13.8K

Related Experiment Videos

Last Updated: Jan 4, 2026

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing
08:34

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing

Published on: January 2, 2018

9.9K
Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.1K
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

13.8K

Area of Science:

  • Cellular mechanics
  • Developmental biology
  • Wound healing research

Background:

  • Epithelial tissue collective cell behavior relies on mechanical properties.
  • The role of tissue mechanics in in vivo wound healing is not well understood.

Purpose of the Study:

  • Investigate the relationship between tissue mechanics and wound healing.
  • Determine how altering epithelial cell junctional tension affects wound healing rates in Drosophila.

Main Methods:

  • Utilized live Drosophila wing imaginal discs for in vivo experiments.
  • Employed a cell-based physical model to simulate tissue behavior.
  • Measured cell intercalation rates and tissue viscosity.

Main Results:

  • Tuning epithelial cell junctional tension systematically altered wound healing rates.
  • Observed cell intercalation at the wound edge, resembling fluid flow.
  • Reduced junctional tension led to tissue fluidization via increased intercalation and decreased viscosity, akin to an unjamming transition.

Conclusions:

  • Tissue fluidization through reduced junctional tension accelerates wound healing.
  • Experimental reduction of tissue tension in Drosophila wing discs increased intercalation rates and shortened repair time.