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CRY arrests Cop1 to regulate circadian rhythms in mammals

Choogon Lee1

  • 1Department of Biomedical Sciences, Program in Neuroscience, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306 USA.

Cell Division
|November 9, 2019
PubMed
Summary

Cryptochromes (CRYs) antagonize Cop1 activity in mammals by displacing it from a key complex, revealing an ancient conserved pathway. This mechanism, repurposed from plant photomorphogenesis, regulates mammalian circadian rhythms.

Keywords:
CRL4Circadian rhythmsCop1CryptochromeE3 ligaseGlucocorticoid receptorGlucocorticoidsGluconeogenesisTranscriptional negative feedback loop

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