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Related Experiment Video

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Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
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Worldwide perspectives on venom allergy.

Peter Korošec1, Thilo Jakob2, Harfi Harb3

  • 1University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.

The World Allergy Organization Journal
|November 9, 2019
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Summary

Venom immunotherapy effectively prevents severe allergic reactions. Global access to standardized, locally relevant venom extracts is crucial but currently lacking, necessitating new product development and improved healthcare support.

Keywords:
ImmunotherapyInsectsVenomVenom immunotherapy

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Area of Science:

  • Allergy and Immunology
  • Public Health
  • Pharmacology

Background:

  • Venom immunotherapy is the standard treatment for severe insect sting allergies, reducing anaphylaxis risk.
  • Insect venom allergies vary regionally, with common culprits like bees, wasps, and ants, and specific regional threats like ticks and kissing bugs.
  • Current venom immunotherapy products face global access and standardization challenges.

Purpose of the Study:

  • To highlight the critical need for worldwide availability of standardized, locally relevant venom extracts for allergy diagnosis and treatment.
  • To emphasize the deficiencies in current venom immunotherapy products and the necessity for new, improved formulations.
  • To advocate for global promotion and support of venom immunotherapy by health and regulatory authorities.

Main Methods:

  • Review of current literature on venom immunotherapy efficacy and global availability.
  • Analysis of regional variations in venomous insects causing severe allergic reactions.
  • Assessment of deficiencies in existing commercial venom extracts and therapeutic vaccines.

Main Results:

  • Venom immunotherapy significantly reduces the risk of future anaphylactic events.
  • There is a substantial global disparity in access to high-quality, standardized venom immunotherapy for locally relevant allergens.
  • Many existing commercial venom products are unstandardized, inadequate, or unavailable in many regions.

Conclusions:

  • Ensuring worldwide availability of standardized venom extracts is a moral imperative.
  • New, improved venom immunotherapy products are required, especially for insects lacking current treatment options.
  • Global promotion and support from health authorities are essential for effective venom immunotherapy provision.