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Updated: Jan 4, 2026

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Published on: June 16, 2020
Carcinoid Syndrome-Induced Scleroderma-Like Disease
Karen Koch1, Wayne Grayson2,3
1Dermatology Department, Wits University Donald Gordon Medical Centre, Johannesburg, South Africa.
Abstract:
Scleroderma is a rare complication of carcinoid syndrome and is usually encountered in the setting of a metastatic primary neuroendocrine tumour of the distal ileum. Associated endocardial fibrosis is a frequent finding and the condition carries a poor prognosis. We report a case of scleroderma occurring in a 72-year-old female with metastatic neuroendocrine carcinoma and associated pericardial fibrosis. The use of an alternative nomenclature such as "scleroderma-like" or "sclerodermoid" disease is proposed in order to emphasise its distinction from true idiopathic scleroderma, despite the histopathological similarities on skin biopsy.
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