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Primary Cutaneous Anaplastic Large-Cell Lymphoma.

Nerissa Moodley¹, Patiswa Nombona¹, Anisa Mosam¹

¹Nelson R Mandela School of Medicine, Department of Dermatology, University of KwaZulu-Natal, Durban, South Africa.

Dermatopathology (Basel, Switzerland)

|November 9, 2019

Summary

A rare T-cell anaplastic large-cell lymphoma presented as self-healing skin lesions. The condition transformed into a systemic variant post-chemotherapy, highlighting its aggressive potential.

Keywords:

Anaplastic large cell lymphoma Peripheral T cell lymphoma Primary cutaneous anaplastic large-cell lymphoma

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Anaplastic large-cell lymphoma (ALCL), T-cell type, is a distinct வகை of non-Hodgkin lymphoma.
Cutaneous manifestations of ALCL can vary, sometimes presenting as atypical lymphoid-type cells.

Observation:

A 35-year-old male exhibited asymptomatic, generalized, self-healing skin lesions over six months.
Clinical examination revealed diffuse, ulcerated, necrotic papules and nodules, accompanied by facial lymphoedema.

Findings:

Histopathology confirmed atypical lymphoid-type cells with round-to-oval shapes and irregular, horseshoe-shaped nuclei.
Immunohistochemistry demonstrated positivity for CD30, CD3, and epithelial membrane antigen.
The findings were consistent with anaplastic large-cell lymphoma, T-cell type.

Implications:

This case highlights a rare presentation of T-cell anaplastic large-cell lymphoma with initial cutaneous involvement.
The transformation to a systemic variant post-chemotherapy underscores the need for vigilant monitoring.
Understanding these presentations is crucial for accurate diagnosis and management of cutaneous lymphomas.