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JMJD3 in the regulation of human diseases

Xiangxian Zhang1, Li Liu1, Xia Yuan1

  • 1Laboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.

Protein & Cell
|November 9, 2019
PubMed

Insights

Histone methylation regulates gene expression in diseases. The JMJD3 protein demethylates H3K27me2/3, impacting various human conditions like cancer and immune disorders.

Area of Science:

  • Epigenetics and Molecular Biology
  • Human Disease Mechanisms

Background:

  • Histone methylation is crucial for gene expression regulation, influencing active and silent states.
  • The Jumonji domain-containing protein D3 (JMJD3) targets histone H3 lysine 27 di- and trimethylation (H3K27me2/3).
  • JMJD3's role is increasingly recognized across diverse pathologies, including immune, infectious, oncologic, developmental, and aging-related diseases.

Purpose of the Study:

  • To review recent advancements in understanding JMJD3's function in human diseases.
  • To provide insights into the future research directions for the JMJD3 gene.

Main Methods:

  • Literature review of recent studies on JMJD3.
  • Analysis of JMJD3's specific demethylation activity on H3K27me2/3.
  • Synthesis of findings across various disease contexts.

Main Results:

  • JMJD3's critical role in modulating gene expression through H3K27me2/3 demethylation is highlighted.
  • Evidence links JMJD3 dysregulation to the pathogenesis of numerous human diseases.
  • Specific examples of JMJD3 involvement in immune, infectious, cancer, developmental, and aging diseases are discussed.

Conclusions:

  • JMJD3 is a significant epigenetic regulator with broad implications in human health and disease.
  • Further research into JMJD3 mechanisms and therapeutic targeting holds promise for treating various conditions.
  • Understanding JMJD3's multifaceted roles is essential for advancing precision medicine.
Keywords:
JMJD3epigeneticshistone methylationhuman diseases

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