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Monensin and bile protein secretion. A tool to investigate hepatocyte intracellular vesicular polarity
A Casu1, M M Averame, R Piemontese
1Istituto di Patologia Generale, Università, Genova.
The Italian Journal of Biochemistry
|May 1, 1988
Abstract:
Bile derived from monensin treated bile-fistula rats was analysed by SDS-polyacrylamide gels. Differences in proteins were observed for bands presumptively corresponding to transferrin, secretory-IgA and free secretory components after treatment with the ionophore. The results show that the secretion of proteins in bile is differentiated and asyncronous, confirming a polarity of the hepatocyte subcellular compartments.