Tiam1 high expression is associated with poor prognosis in solid cancers: A meta-analysis

Area of Science:

• Oncology
• Molecular Biology
• Cancer Research

Background:

• Previous studies on the prognostic value of T-cell lymphoma invasion and metastasis-inducing factor 1 (Tiam1) in solid cancers yielded inconsistent results.
• A systematic review and meta-analysis was conducted to clarify the prognostic role of Tiam1 expression.

Purpose of the Study:

• To evaluate the prognostic significance of Tiam1 expression in patients diagnosed with solid cancers.
• To determine the association between Tiam1 expression levels and patient survival outcomes.

Main Methods:

• A comprehensive literature search was performed across PubMed, Web of Science, and CNKI databases for studies published between 1994 and April 2019.
• Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were extracted to assess the relationship between Tiam1 expression and overall survival (OS) and disease-free survival (DFS).

Main Results:

• The meta-analysis included data from 20 studies encompassing 2647 patients with solid cancers.
• Elevated Tiam1 expression was significantly correlated with poorer OS (HR = 2.17) and DFS (HR = 1.95).
• Subgroup and sensitivity analyses confirmed the reliability and stability of the findings.

Conclusions:

• This meta-analysis provides robust evidence that higher Tiam1 expression is associated with adverse outcomes in solid cancer patients.
• Tiam1 may serve as a valuable prognostic predictor and a potential therapeutic target for solid cancers.
• Further homogeneous and prospective studies are recommended to validate these findings.