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Related Concept Videos

Inflammation01:38

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Related Experiment Video

Updated: Jan 4, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
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Adaptive immunity-driven inflammation and cardiovascular disease.

Daria V Ilatovskaya1,2, Ganesh V Halade3, Kristine Y DeLeon-Pennell4,5

  • 1Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

American Journal of Physiology. Heart and Circulatory Physiology
|November 9, 2019
PubMed
Summary

The adaptive immune response plays a key role in cardiovascular diseases like atherosclerosis and heart failure, but its precise functions require further study. This review synthesizes current research on immune cells and inflammation in cardiovascular conditions.

Keywords:
adaptive immunityatherosclerosiseosinphiliahypertensionmyocardial infarction

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Area of Science:

  • Cardiovascular Physiology
  • Immunology
  • Inflammation Biology

Background:

  • Adaptive immunity is increasingly recognized as a significant factor in cardiovascular disorders such as atherosclerosis, hypertension, cardiac remodeling, and heart failure.
  • The intricate interplay between innate immune cells (neutrophils, monocytes/macrophages) and adaptive immune cells (T cells, dendritic cells, B cells) in cardiovascular disease necessitates further investigation.
  • A consensus on the temporal aspects, cellular phenotypes, and inflammatory processes of adaptive immunity in cardiovascular contexts is currently lacking.

Purpose of the Study:

  • To review and summarize key findings from 15 articles, including 7 reviews, addressing adaptive immunity in cardiovascular disease.
  • To consolidate crucial insights at the cardiac, vascular, immune, and molecular levels.
  • To discuss the translational potential and advantages of future research directions in adaptive immunity and cardiovascular disease.

Main Methods:

  • Systematic review and synthesis of 15 published articles (7 reviews) from a special issue on Adaptive Immunity in Cardiovascular Disease.
  • Analysis of findings pertaining to immune cell involvement and inflammatory pathways.
  • Evaluation of the translational feasibility of current research and future prospective studies.

Main Results:

  • Adaptive immune responses are integral to various cardiovascular conditions, influencing cardiac and vascular functions.
  • Specific cellular phenotypes and inflammatory cascades involving both innate and adaptive immune systems are critical.
  • Research highlights the complex molecular mechanisms underlying immune system involvement in cardiovascular pathology.

Conclusions:

  • Adaptive immunity is a critical, yet not fully understood, component of cardiovascular disease pathogenesis.
  • Further research is essential to clarify the roles of specific immune cells and inflammatory processes.
  • Translational studies focusing on adaptive immunity hold promise for novel therapeutic strategies in cardiovascular medicine.