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A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular

Marianna Holczer1, Bence Hajdú1, Tamás Lőrincz2

  • 1Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1085 Budapest, Hungary.

International Journal of Molecular Sciences
|November 10, 2019
PubMed
Summary

Cellular nutrient sensing relies on the AMPK-mTORC1-ULK1 pathway. A double negative feedback loop between AMPK and mTORC1 ensures proper autophagy regulation during changing nutrient and energy conditions.

Keywords:
AMPKautophagydouble negative feedbackmTORsystems biology

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