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Related Experiment Videos

Blastomycosis in cats: five cases (1979-1986).

M A Breider1, T L Walker, A M Legendre

  • 1Department of Pathobiology, College of Veterinary Medicine, Universityof Tennessee, Knoxville 37901-1071.

Journal of the American Veterinary Medical Association
|September 1, 1988
PubMed
Summary

Blastomycosis in cats often affects the respiratory system and can spread to other organs. Diagnosis involves identifying the fungus, and treatment with amphotericin B was ineffective in this study.

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Area of Science:

  • Veterinary Medicine
  • Mycology
  • Infectious Diseases

Background:

  • Blastomycosis is a systemic fungal infection caused by *Blastomyces dermatitidis*.
  • It can affect various organs in domestic animals, including cats.
  • Understanding feline blastomycosis is crucial for diagnosis and treatment.

Purpose of the Study:

  • To review medical records of cats diagnosed with blastomycosis.
  • To describe the clinical signs, diagnostic methods, and outcomes of blastomycosis in cats.
  • To evaluate the efficacy of amphotericin B treatment in affected felines.

Main Methods:

  • Retrospective review of medical records from 5 cats with blastomycosis.
  • Examination of clinical signs, diagnostic findings (biopsy/necropsy), and treatment responses.

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  • Histopathological analysis of affected tissues to identify fungal organisms and host response.

    • Main Results:

    • Respiratory tract disease was the most common clinical sign, followed by central nervous system (CNS) and ocular signs.
    • Definitive diagnosis was confirmed by identifying *Blastomyces dermatitidis* in biopsy or necropsy specimens.
    • Two cats treated with amphotericin B showed no improvement and were euthanized or died.
    • Commonly affected organs included lungs, brain, eyes, and lymph nodes, with one cat presenting with only cutaneous and lymph node involvement.
    • The respiratory tract was often the primary site of infection, with subsequent dissemination.

    Conclusions:

    • Feline blastomycosis presents with diverse clinical signs, frequently involving the respiratory system.
    • Diagnosis relies on identifying the characteristic fungus in tissue samples.
    • Amphotericin B demonstrated limited efficacy in treating blastomycosis in this feline cohort.
    • The pyogranulomatous inflammatory response with abundant fungal organisms is typical in affected cats.