Related Experiment Video
Updated: Jan 4, 2026
07:38
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
585
Wnt Signalling in Acute Myeloid Leukaemia
Alicja M Gruszka1, Debora Valli1, Myriam Alcalay1,2
1Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Via Adamello 16, 20 139 Milan, Italy.
Cells
|November 10, 2019
Summary
Acute myeloid leukaemia (AML) involves mutations activating Wnt signalling, crucial for leukaemic stem cells. Targeting this pathway shows promise, but clinical efficacy requires further validation.
Area of Science:
- Hematology
- Cancer Biology
- Molecular Oncology
Background:
- Acute myeloid leukaemia (AML) is a malignancy of hematopoietic stem/progenitor cells.
- Aberrant Wnt signalling, through mutations or antagonist inactivation, drives AML pathogenesis.
- Wnt signalling is essential for sustaining leukaemic stem cells in AML.
Purpose of the Study:
- To review the role of Wnt signalling in AML.
- To identify key molecules within the Wnt pathway that have prognostic value in AML.
- To assess the therapeutic potential of targeting Wnt signalling in AML.
Main Methods:
- Literature review of studies on Wnt signalling in AML.
- Analysis of prognostic markers associated with Wnt pathway components.
- Evaluation of preclinical data for Wnt-targeted therapies in AML.
Main Results:
- Numerous Wnt signalling molecules (e.g., β-catenin, LEF-1, AXIN2) exhibit prognostic significance in AML.
- Wnt pathway activation is a common mechanism in AML development and maintenance.
- Preclinical studies demonstrate the feasibility of targeting Wnt signalling.
Conclusions:
- Wnt signalling is a critical driver and therapeutic target in Acute Myeloid Leukaemia.
- Specific Wnt pathway molecules serve as important prognostic indicators.
- Further clinical trials are needed to establish the efficacy of Wnt-targeted therapies in AML.
More Related Videos
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.6K
10:21Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
10.4K
Related Concept Videos
02:54Canonical Wnt Signaling Pathway
10.3K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.3K
01:41Non-Canonical Wnt Signaling Pathways
8.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.2K
02:23Abnormal Proliferation
5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
01:15Differentiation of Common Myeloid Progenitor Cells
3.8K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K
01:17Intracellular Signaling Affects Focal Adhesions
3.4K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
3.4K
03:14Notch Signaling Pathway
6.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.3K