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Study on the interactions between B-norcholesteryl benzimidazole compounds with ct-DNA

Chunfang Gan1, Xiaotong Huang1, Junyan Zhan1

  • 1Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, School of Chemistry and Material, Nanning Normal University, Nanning, 530001, PR China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|November 10, 2019
PubMed
Summary

Novel B-norcholesteryl benzimidazole compounds interact with DNA, primarily through intercalation. This binding mechanism correlates with their anticancer activity, offering insights for developing new B-norsteroidal anticancer agents.

Keywords:
B-norcholesteryl benzimidazoleB-norsteroidsIntercalationMTTSpectrometryct-DNA

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