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Updated: Jan 4, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Correlation between spinal cord diffusion tensor imaging and postural response latencies in persons with multiple

Chu-Yu Lee1, Jessie M Huisinga2, In-Young Choi3

  • 1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA.

Magnetic Resonance Imaging
|November 10, 2019
PubMed
Summary

Delayed postural responses in multiple sclerosis (MS) are linked to spinal cord damage. Lower fractional anisotropy (FA) in the cervical spinal cord correlates with longer response latencies, indicating impaired microstructure.

Keywords:
Diffusion tensor imagingMicrostructureMultiple sclerosisPostural responseSpinal cord

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Radiology

Background:

  • Delayed postural responses in multiple sclerosis (MS) are associated with imbalance and increased fall risk.
  • Spinal cord microstructural integrity, particularly in the cervical region, may underlie these delays.
  • Diffusion Tensor Imaging (DTI) offers a method to assess spinal cord microstructure.

Purpose of the Study:

  • To investigate the correlation between postural response latency and cervical spinal cord microstructural integrity in MS patients.
  • To utilize DTI metrics to quantify spinal cord microstructure and relate it to functional outcomes.

Main Methods:

  • Seventeen individuals with mild-to-moderate MS underwent postural response latency measurements (tibialis anterior and gastrocnemius muscles) via electromyography.
  • Cervical spinal cord DTI was performed, measuring mean, radial, axial diffusivity, and fractional anisotropy (FA) between C4-C6.
  • Spearman's rank correlation assessed relationships between DTI metrics, postural latencies, Expanded Disability Status Scale (EDSS), and 25-foot walk (T25FW) scores.

Main Results:

  • Lower FA in the cervical spinal cord significantly correlated with longer latencies in the right tibialis anterior muscle during forward postural perturbations (r=-0.51, p=0.04).
  • No significant correlations were found between DTI metrics and EDSS scores or T25FW.
  • No significant differences in DTI metrics were observed between subjects with and without spinal cord lesions.

Conclusions:

  • Impaired cervical spinal cord microstructure, as indicated by lower FA, is associated with delayed postural responses in individuals with MS.
  • DTI-derived microstructural integrity may serve as a biomarker for assessing functional deficits related to postural control in MS.