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Updated: Jan 4, 2026
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study
Koustav Chatterjee1, Akash Roy2, Rebecca Banerjee1
1Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India.
Background:
Alpha-synuclein and inflammatory pathology are evident in Parkinson's disease (PD) but, their link to disease pathogenesis needs further elucidation.
Objectives:
To explore α-synuclein-mediated inflammation in the serum of PD patients and its link with disease severity.
Methods:
Serum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein were compared.
Results:
IL-1β, NLRP3 levels were significantly increased in PD. We also observed a linear correlation of NLRP3 with α-synuclein. Phosphorylated α-synuclein levels were significantly elevated in later stages of PD.
Conclusions:
The α-synuclein-NLRP3 mediated inflammation may underline the pathophysiology of PD and might serve as a novel therapeutic target in PD.
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