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Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males

Linfang Zhang1, Zhiheng Chen2, Xiujuan Xia1

  • 1Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.

Atherosclerosis
|November 10, 2019
PubMed

Insights

Helicobacter pylori infection is linked to carotid atherosclerosis in young males under 50. Persistent H. pylori infection increases the risk of developing carotid atherosclerosis in this demographic.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Atherosclerosis contributes significantly to cardiovascular mortality.
  • The association between Helicobacter pylori (H. pylori) infection and atherosclerosis remains debated.
  • This study investigates the link between H. pylori infection and carotid atherosclerosis.

Purpose of the Study:

  • To determine if H. pylori infection is associated with carotid atherosclerosis.
  • To evaluate H. pylori's role as a risk factor for carotid atherosclerosis.
  • To analyze the impact of H. pylori on the development and progression of carotid atherosclerosis.

Main Methods:

  • Screened 12,836 individuals (March 2012-March 2017) using carotid ultrasound and 13C-urea breath test.
  • Collected baseline demographics, cardiac risk factors, and laboratory data.
  • Analyzed 5-year follow-up data for 1216 subjects to assess carotid atherosclerosis development and progression.

Main Results:

  • H. pylori infection independently predicts carotid atherosclerosis in males under 50 (OR 1.229, p=0.009) after adjusting for confounders.
  • No significant association was found in older males or females.
  • Young males with persistent H. pylori infection showed a higher incidence of new carotid atherosclerosis lesions (p=0.028) over 3 years.

Conclusions:

  • H. pylori infection may be an important risk factor for carotid atherosclerosis in young Chinese males.
  • The findings highlight a specific demographic at increased risk.
  • Further research may elucidate the mechanisms linking H. pylori to atherosclerosis in this population.
Abstract

Keywords:
Cardiovascular risk factorCarotid atherosclerosisGender differenceHelicobacter pylori

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