T. gondii inveSTING in a latent future
Ramya Nandakumar1, Søren R Paludan2
1Department of Biomedicine, Aarhus University, CF Mφllers Alle 6, Building 1115, Aarhus C DK-8000, Denmark.
The Journal of Biological Chemistry
|November 10, 2019
Summary
Toxoplasma gondii infection is controlled by the parasite protein GRA15, which activates the STING pathway. This host defense limits parasite replication, promoting chronic infection and latency.
Area of Science:
- Immunology
- Parasitology
- Cell Biology
Background:
- Toxoplasma gondii is an obligate intracellular protozoan parasite infecting mammals.
- The parasite manipulates the host environment to establish chronic infections and latency.
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