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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-Like Behavior.

Jianfeng Liu1, Ruyan Wu2, Bernard Johnson2

  • 1Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York 14214 jliu66@buffalo.edu junxuli@buffalo.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 10, 2019
PubMed
Summary

The claustrum-prefrontal cortex pathway regulates impulsivity in rats. This pathway is crucial for controlling impulsive behaviors and may be a target for treating addiction.

Keywords:
5-CSRTTclaustrumimpulsivityprefrontal cortexrat

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience

Background:

  • The function of the claustrum (CLA) and its projections to cortical areas, particularly the prefrontal cortex (PFC), is largely unknown.
  • Understanding these pathways is crucial for deciphering brain functions and disorders.

Purpose of the Study:

  • To investigate the role of the CLA-PFC neural projections in regulating impulsivity in male rats.
  • To determine if this pathway is involved in drug-induced impulsivity.

Main Methods:

  • Used retrograde tracers and viral expression to identify the CLA-PFC pathway.
  • Employed chemogenetics (DREADDs) to activate or inhibit CLA-PFC pathway activity.
  • Assessed neural activity using c-Fos staining and behavioral impulsivity using the 5-choice serial reaction time task (5-CSRTT).

Main Results:

  • Chemogenetic activation of CLA-PFC reduced PFC activity and increased impulsive-like behavior (premature responses).
  • Chemogenetic inhibition of CLA-PFC increased PFC activity and reduced impulsive-like behavior.
  • CLA-PFC pathway inhibition prevented methamphetamine-induced impulsivity without affecting hyperactivity.
  • Claustrum activation alone disrupted attention.

Conclusions:

  • The CLA-PFC pathway is essential for regulating impulsivity.
  • This pathway plays a selective role in impulsivity, distinct from general activity or attention.
  • The CLA-PFC pathway represents a potential therapeutic target for impulsivity-related disorders like drug addiction.