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Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with
T Moriyama1, H Takamura, H Narita
1Research Institute for Food Science, Kyoto University.
Journal of Biochemistry
|June 1, 1988
Abstract:
The thromboxane A2 antagonist, ONO-3708, completely inhibited the increase in cytosolic free Ca2+ in human platelets during activation with collagen. Half-maximal Ca2+ release and influx required about 3 and 4 nM STA2, a stable thromboxane A2 mimetic, respectively. However, half maximal activation of phospholipase C required about 18 nM STA2. This suggests that thromboxane A2 directly causes Ca2+ mobilization without further activation of phospholipase C during activation of human platelets with collagen.