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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Familial Mediterranean fever and atherosclerosis in childhood and adolescence

Olga Vampertzi1, Kyriaki Papadopoulou-Legbelou2, Areti Triantafyllou3

  • 14th Department of Pediatrics, "Papageorgiou" Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. olgastrieste@hotmail.com.

Rheumatology International
|November 10, 2019
PubMed

Insights

Familial Mediterranean Fever (FMF) patients may have ongoing inflammation, increasing risks for endothelial dysfunction and atherosclerosis. Early detection methods are crucial for managing cardiovascular disease in children with FMF.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pediatrics

Background:

  • Familial Mediterranean Fever (FMF) is a chronic inflammatory condition causing recurrent fever and polyserositis.
  • Colchicine therapy manages FMF, but subclinical inflammation may persist, potentially leading to endothelial dysfunction and atherosclerosis.
  • Atherosclerosis is a significant long-term complication linked to chronic inflammatory diseases.

Purpose of the Study:

  • To review the association between FMF and atherosclerosis.
  • To explore novel serum inflammatory markers for FMF.
  • To identify non-invasive methods for early endothelial dysfunction detection in children with FMF.

Main Methods:

  • Systematic literature search of MEDLINE/PubMed, Scopus, and Web of Science.
  • Inclusion of peer-reviewed studies and reviews in English.
  • Keywords: familial Mediterranean fever, children, endothelial dysfunction, atherosclerosis, cardiovascular disease.

Main Results:

  • Evidence suggests a link between FMF and accelerated atherosclerosis.
  • Emerging inflammatory markers show promise in assessing disease activity.
  • Non-invasive techniques can detect early endothelial dysfunction.

Conclusions:

  • Subclinical inflammation in FMF contributes to cardiovascular risk.
  • Early identification of endothelial dysfunction and atherosclerosis in children with FMF is vital.
  • Further research into novel markers and non-invasive diagnostics is warranted for proactive cardiovascular care.
Keywords:
AtherosclerosisCardiovascular diseaseChildrenEndothelial dysfunctionFamilial Mediterranean fever

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