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Published on: September 25, 2011
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[Morphomolecular characterization of colorectal neoplasms]
1Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Trogerstraße 18, 81675, München, Deutschland. moritz.jesinghaus@tum.de.
Der Pathologe
|November 10, 2019
Summary
Molecular characterization of colorectal neoplasias using targeted massive parallel sequencing (MPS) aids diagnosis. This approach identifies therapeutic targets and distinct tumor subtypes, improving clinical pathology.
Area of Science:
- Oncology
- Molecular Pathology
- Genomics
Background:
- Molecular characterization is increasingly central to clinical pathology.
- Linking tumor morphology to molecular alterations aids diagnosis and identifies therapeutic targets.
Purpose of the Study:
- To perform morphomolecular characterization of colorectal neoplasias.
- To investigate distinct morphologies and specific clinical settings.
Main Methods:
- Targeted massive parallel sequencing (MPS) was employed.
- Analysis of various colorectal neoplasias.
Main Results:
- MPS demonstrated clinical utility in routine molecular diagnostics of colorectal carcinoma (CRC).
- A close genetic relationship was found between colorectal adenoneuroendocrine carcinomas and classical CRC.
- Appendiceal goblet cell neoplasias exhibit a distinct genetic profile.
Conclusions:
- Morphomolecular characterization identifies therapeutically relevant alterations.
- This approach allows specific identification of morphologically distinct colorectal neoplasia subtypes for diagnostic use.
Keywords:
Appendiceal neoplasmsColorectal carcinomaColorectal tumorsHigh-throughput nucleotide sequencingPrecision oncology
