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Related Experiment Video

Updated: Jan 4, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

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[Predictive biomarkers in bladder cancer].

H Reis1, T Szarvas2,3

  • 1Institut für Pathologie, Westdeutsches Tumorzentrum, Universitätsmedizin Essen, Universität Duisburg-Essen, Essen, Deutschland. Henning.Reis@uk-essen.de.

Der Pathologe
|November 10, 2019
PubMed
Summary
This summary is machine-generated.

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Histotype-specific incidence and survival of urothelial carcinoma-an analysis of the German North Rhine-Westphalia Cancer Registry.

ESMO real world data and digital oncology·2026
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Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma.

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[German expert consensus on programmed cell death ligand 1 (PD-L1) testing in perioperative systemic therapy of muscle invasive bladder cancer].

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Comparative analysis of Bricker versus Wallace ureteroenteric anastomosis and identification of predictors for postoperative ureteroenteric stricture.

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[Nodular tumour of the Vas deferens with epithelial structures].

Der Pathologe·2021

Molecular subtypes predict treatment response in advanced urothelial bladder cancer, guiding chemotherapy and immunotherapy. Further research is needed to fully understand their predictive roles and identify new biomarkers.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Cancer Therapeutics

Background:

  • Advanced urothelial bladder cancer treatment has seen significant therapeutic advancements.
  • Personalized medicine approaches are increasingly important for optimizing patient outcomes.

Purpose of the Study:

  • To provide an overview of current and future therapeutic options for advanced urothelial bladder cancer.
  • To highlight the role of molecular pathology in identifying therapy-predictive markers.
  • To emphasize the growing importance of pathology in guiding cancer treatment decisions.

Main Methods:

  • Review of current clinical study data and existing literature.
  • Inclusion of expert knowledge and own findings.
  • Focus on therapy prediction for platinum-based chemotherapy, immunotherapy, and other treatments.
Keywords:
Bladder cancerChemotherapyImmunotherapyMIBCUrothelial carcinoma

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Last Updated: Jan 4, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

10.8K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.2K
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
06:23

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

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Main Results:

  • Molecular subtypes demonstrate predictive value for both platinum-based chemotherapy and immunotherapy.
  • Specific DNA damage repair (DDR) gene alterations (ERCC2, ERBB2) and gene expression markers (EMMPRIN, survivin, HMGA2) show promise for chemotherapy efficacy prediction.
  • Tumor mutation burden (TMB), tumor neoantigen burden (TNB), APOBEC signatures, and CD8+ T-cell signatures are key for predicting immunotherapy response.

Conclusions:

  • Molecular subtypes are valuable predictors of treatment response in urothelial bladder cancer.
  • Further investigation is necessary to fully elucidate the predictive capabilities of molecular subtypes.
  • Biomarkers such as DDR gene alterations, specific gene expressions, and immune signatures are crucial for personalized therapy selection.