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Related Concept Videos

Motor Unit Stimulation01:20

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When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
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Updated: Jan 4, 2026

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
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Functional Electrical Stimulation Cycling Exercise for People with Multiple Sclerosis.

Lara A Pilutti1, Robert W Motl2

  • 1Interdisciplinary School of Health Sciences, Brain and Mind Research Institute, University of Ottawa, Ottawa, Canada.

Current Treatment Options in Neurology
|November 10, 2019
PubMed
Summary

Functional electrical stimulation (FES) cycling shows promise for improving fitness and reducing fatigue in individuals with advanced multiple sclerosis (MS). More high-quality trials are needed to confirm these benefits for exercise management in MS.

Keywords:
CyclingExerciseFunctional electrical stimulationMultiple sclerosis

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Exercise is crucial for managing multiple sclerosis (MS) but challenging for those with advanced disability.
  • Functional electrical stimulation (FES) cycling offers a potential solution for exercise delivery in this population.

Purpose of the Study:

  • To review current evidence on FES cycling for individuals with MS.
  • To assess FES cycling's prescription, safety, tolerability, and effects (acute and chronic).

Main Methods:

  • Literature search for studies on FES cycling in MS up to July 2019.
  • Analysis of eight retrieved studies, noting low overall quality and one small randomized controlled trial (RCT).

Main Results:

  • Limited but promising evidence suggests FES cycling is feasible and safe for individuals with moderate-to-severe MS.
  • Preliminary findings indicate potential benefits for physiological fitness, walking mobility, fatigue, and pain.
  • Participants tolerated regular FES cycling (30 min, 2-3x/week) with few adverse events.

Conclusions:

  • FES cycling is a promising exercise modality for individuals with advanced MS.
  • High-quality RCTs are essential to establish evidence-based recommendations for FES cycling in advanced MS management.