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Inflammatory serum markers predicting spontaneous ureteral stone passage
Nassib Abou Heidar1, Muhieddine Labban1, Gerges Bustros1
1Division of Urology, Department of Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.
Clinical and Experimental Nephrology
|November 10, 2019
Summary
Higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) indicate a lower chance of spontaneous ureteral stone passage (SSP). These inflammatory markers may aid in clinical decisions for managing ureteral stones.
Area of Science:
- Urology
- Nephrology
- Emergency Medicine
Background:
- Ureteral stones cause significant healthcare and economic burdens.
- Predictors for spontaneous ureteral stone passage (SSP) remain poorly understood.
- Current management ranges from observation to surgical intervention.
Purpose of the Study:
- To investigate the association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with SSP.
- To identify novel inflammatory markers for predicting ureteral stone passage.
- To inform clinical decision-making in emergency departments.
Main Methods:
- Retrospective chart review of 619 patients with ureteral stones (<10 mm) admitted to the ED.
- Collected demographic, clinical, laboratory, and radiological data.
- Utilized Linear-by-Linear Association, univariate analysis, and multivariate logistic regression with bootstrapping for NLR and PLR.
Main Results:
- Elevated NLR (>2.87) and PLR (>10.42) were significantly associated with a higher odds of retained ureteral stones.
- Specific NLR and PLR ranges demonstrated increased odds of failed SSP.
- Diabetes, urine leukocytes, hydronephrosis, and stone size were also significant predictors.
Conclusions:
- Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inversely correlated with spontaneous ureteral stone passage (SSP).
- NLR and PLR serve as valuable inflammatory markers.
- These markers can assist in clinical decisions regarding ureteral stone management.
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