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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Novel Embolic Protection Device: a Feasibility Study.

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A novel device reroutes emboli in the aortic arch, offering a new stroke prevention method for high-risk patients. This endovascular approach avoids the bleeding risks associated with anticoagulant therapies.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Neurology

Background:

  • Stroke is a leading global cause of death, with ischemic stroke often caused by cardiac emboli in patients with conditions like atrial fibrillation.
  • Current treatments, primarily anticoagulants, carry risks of severe bleeding, necessitating alternative stroke prevention strategies.
  • There is a critical need for device-based interventions for continuous stroke prevention in high-risk populations.

Purpose of the Study:

  • To develop and evaluate a novel endovascular device for continuous stroke prevention.
  • To assess the feasibility of an implantable device in the aortic arch to reroute emboli away from cerebral arteries.
  • To provide an alternative stroke prevention method for patients with contraindications to anticoagulation.

Main Methods:

  • Design of a novel endovascular tubular mesh device intended for implantation in the aortic arch.
  • In vitro testing to evaluate the device's performance in preventing ischemic stroke.
  • Simulation of cerebral perfusion pressures and assessment of embolic particle diversion efficacy.

Main Results:

  • The endovascular device did not negatively impact simulated cerebral perfusion pressures.
  • The device demonstrated efficient diversion of clinically relevant embolic particles away from cerebral circulation.
  • Feasibility of the device for rerouting cardio-emboli was confirmed in vitro.

Conclusions:

  • The novel endovascular tubular mesh device shows promise as a new approach for stroke prevention.
  • This device offers a potential alternative to anticoagulation for high-risk patients, particularly those with contraindications.
  • Further investigation into this device-based strategy could significantly impact ischemic stroke prevention.