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Sarcopenia and fatty liver disease
1Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, 148 Guro-Dong, Guro-Gu, Seoul, 08308, South Korea.
Hepatology International
|November 10, 2019
Summary
Non-alcoholic fatty liver disease (NAFLD) is linked to sarcopenia, a muscle-wasting condition. Understanding this connection may help prevent fatty liver disease progression.
Area of Science:
- Hepatology and Geriatrics
Background:
- Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition, potentially advancing to non-alcoholic steatohepatitis.
- Sarcopenia, characterized by muscle mass and strength loss, is increasingly common in aging populations.
Purpose of the Study:
- To review the relationship between NAFLD and sarcopenia.
- To discuss the shared pathophysiology and diagnostic challenges.
Main Methods:
- Literature review of clinical studies and pathophysiological mechanisms.
- Analysis of diagnostic criteria for NAFLD and sarcopenia.
Main Results:
- A positive correlation exists between sarcopenia and NAFLD.
- Shared factors include insulin resistance, obesity, inflammation, vitamin D deficiency, inactivity, hepatokines, and myokines.
Conclusions:
- The association between sarcopenia and NAFLD warrants further investigation.
- Recognizing this link may offer strategies for preventing NAFLD deterioration.
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