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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Ketogenic Diet: an Endocrinologist Perspective.

Aravind Reddy Kuchkuntla1, Meera Shah2, Saketh Velapati2

  • 1Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.

Current Nutrition Reports
|November 10, 2019
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Summary
This summary is machine-generated.

The ketogenic diet shows promise for short-term weight loss and improved metabolic health. Long-term effectiveness depends on sustained adherence to carbohydrate restriction, with individual responses varying.

Keywords:
DiabetesKetogenic dietObesityWeight loss

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Area of Science:

  • Metabolic health
  • Nutritional science
  • Endocrinology

Background:

  • Obesity and related comorbidities represent a significant healthcare burden.
  • Current obesity treatments often yield low rates of sustained weight loss.
  • The ketogenic diet, used medically for nearly a century, is regaining popularity for obesity management.

Purpose of the Study:

  • To review current data on the effectiveness and durability of the ketogenic diet for obesity.
  • To compare ketogenic dietary strategies with conventional interventions.
  • To explore the metabolic impact of long-term dietary ketosis.

Main Methods:

  • Systematic review of recent clinical trials.
  • Analysis of data on weight, glycemic control, and endocrine function.
  • Comparison of ketogenic diet outcomes with standard treatments.

Main Results:

  • Recent trials indicate short- and long-term benefits of ketogenic diets on weight and glycemic control.
  • Improvements in endocrine functions, including reproductive hormones, have been observed.
  • The ketogenic diet may offer short-term metabolic improvements with potential for long-term benefits.

Conclusions:

  • Ketogenic dietary strategies show potential for improving metabolic parameters in the short term.
  • Long-term benefits are contingent on the individual's ability to maintain carbohydrate restriction.
  • Further research is needed to fully understand the long-term metabolic effects of dietary ketosis.