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Acmella oleracea for pain management.

Mariangela Rondanelli1, Federica Fossari2, Viviana Vecchio2

  • 1IRCCS Mondino Foundation, Pavia 27100, Italy; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia 27100, Italy.

Fitoterapia
|November 10, 2019
PubMed
Summary

Acmella oleracea demonstrates significant anti-inflammatory, antioxidant, and pain-relieving properties. This botanical holds promise for managing pain, especially in chronic degenerative conditions.

Keywords:
Acmella oleraceaPainSpilanthes acmellaSpilanthol

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Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Pain Management

Background:

  • Millions suffer from pain despite medical advances.
  • Botanical interventions targeting pain pathways are gaining attention.
  • Acmella oleracea is explored for its potential analgesic properties.

Purpose of the Study:

  • To review current knowledge on Acmella oleracea's anti-inflammatory, antioxidant, and analgesic activities.
  • To identify bioactive compounds responsible for these effects.
  • To assess Acmella oleracea's potential in pain management.

Main Methods:

  • Systematic review of 99 eligible studies.
  • Analysis of Acmella oleracea's bioactive compounds, including N-alkylamides (spilanthol).
  • Examination of mechanisms underlying its anti-inflammatory and analgesic effects.

Main Results:

  • Acmella oleracea exhibits confirmed anti-inflammatory and antioxidant activities.
  • Its analgesic effects involve prostaglandin synthesis inhibition, neurotransmitter system activation (opioidergic, serotoninergic, GABAergic), and Na+ channel blockade.
  • Spilanthol is identified as a key compound, particularly for anesthetic activity.

Conclusions:

  • Acmella oleracea possesses significant anti-inflammatory, antioxidant, and analgesic properties.
  • Bioactive compounds like spilanthol contribute to its therapeutic effects.
  • This herb shows promise for managing pain, particularly in chronic degenerative diseases.