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Phages Enter the Fight against Colorectal Cancer
Vinicius Kannen1, Lee Parry2, Francis L Martin3
1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Abstract:
Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
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