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Related Experiment Video

Updated: Jan 4, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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[Breast cancer epidemiology].

Hélène Sancho-Garnier1, Marc Colonna2

  • 1l'Académie nationale de médecine, faculté de médecine de Montpellier, ANM, 75272 Paris, France.

Presse Medicale (Paris, France : 1983)
|November 11, 2019
PubMed
Summary

Breast cancer is a global health concern, with incidence and mortality rates varying worldwide. Early diagnosis and improved treatments have led to declining mortality and high survival rates in countries like France.

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Breast cancer is the most common cancer in women globally, with significant geographical variations in incidence.
  • While incidence has increased in many regions, some countries, including France, have observed a decrease since the early 2000s, possibly linked to reduced menopausal hormone therapy.
  • Breast cancer is a leading cause of cancer death in women, though mortality is declining in industrialized nations due to early detection and better treatments.

Purpose of the Study:

  • To review the global epidemiology of breast cancer, including incidence, mortality, and survival rates.
  • To discuss the identified risk factors for breast cancer, considering their interaction and variability.
  • To evaluate the potential for primary prevention strategies in reducing breast cancer risk.

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Main Methods:

  • Review of epidemiological studies on breast cancer incidence, mortality, and survival.
  • Analysis of identified risk factors and their relative risks.
  • Estimation of attributable risk proportions for primary prevention.

Main Results:

  • Breast cancer incidence varies globally, with France having one of the highest rates in Europe.
  • Mortality rates have declined in industrialized countries over the past 30 years, with 5- and 10-year survival rates in France around 88% and 78%, respectively.
  • Primary prevention strategies could potentially reduce attributable risk by 35% for post-menopausal cancers, with recommendations focusing on lifestyle and medical interventions.

Conclusions:

  • Breast cancer remains a significant global health issue, but advancements in early diagnosis and treatment have improved outcomes.
  • Understanding and addressing modifiable risk factors through primary prevention is crucial.
  • Recommendations for women and physicians aim to reduce exposure to known risk factors and optimize preventive measures.