The neural code of intelligence: From correlation to causation

Research into the neural underpinning of intelligence has mainly adopted a construct perspective: trying to find structural and functional brain characteristics that would accommodate the psychological concept of g. Few attempts have been made to explain intelligence exclusively based on brain characteristics - the brain perspective. From a methodological viewpoint the brain intelligence relation has been studied by means of correlational and interventional studies. The later providing a causal elucidation of the brain - intelligence relation. The best neuro-anatomical predictor of intelligence is brain volume showing a modest positive correlation with g, explaining between 9 to 16% of variance. The most likely explanation was that larger brains, containing more neurons, have a greater computational power and in that way allow more complex cognitive processing. Correlations with brain surface, thickness, convolution and callosal shape showed less consistent patterns. The development of diffusion tensor imaging has allowed researchers to look also into the microstructure of brain tissue. Consistently observed was a positively correlation between white matter integrity and intelligence, supporting the idea that efficient information transfer between hemispheres and brain areas is crucial for higher intellectual competence. Based on functional studies of the brain intelligence relationship three theories have been put forward: the neural efficiency, the P-FIT and the multi demand (MD) system theory. On the other hand, The Network Neuroscience Theory of g, based on methods from mathematics, physics, and computer science, is an example for the brain perspective on neurobiological underpinning of intelligence. In this framework network flexibility and dynamics provide the foundation for general intelligence. With respect to intervention studies the most promising results have been achieved with noninvasive brain stimulation and behavioral training providing tentative support for findings put forward by the correlational approach. To date the best consensus based on the diversity of results reported would be that g is predominantly determined by lateral prefrontal attentional control of structured sensory episodes in posterior brain areas. The capacity of flexible transitions between these network states represents the essence of intelligence - g.