Related Experiment Video
Updated: Jan 4, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
The role of long non-coding RNAs in the pathogenesis of thyroid cancer
Soudeh Ghafouri-Fard1, Hossein Mohammad-Rahimi2, Mohammad Taheri3
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Long noncoding RNAs (lncRNAs) as prominent regulators of gene expression are involved in different layers of expression regulation. These transcripts participate in carcinogenesis of several human malignancies including thyroid cancer. Availability of high throughput techniques such as RNA sequencing and microarray has facilitated identification of lncRNAs whose dysregulation affect tumorigenesis process. Moreover, assessment of differentially expressed lncRNAs between resistant and sensitive cells has led to recognition of biomarkers for therapeutic response. One elucidated aspect of lncRNAs functions is their role in sponging miRNAs. Several miRNA-lncRNA-mRNA triplets have been recognized till now. Any of these triplets is a putative target of interfering with the evolution of cancer. In the current study, we have summarized recent data in the fields of biology of lncRNAs, their role in thyroid cancer and their potential as biomarker or treatment target.
Related Concept Videos
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Types of RNA
RNA Performs Diverse...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Non-LTR Retrotransposons
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
